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Mitochondrial and ER production of ROS contributes to the processes of aging as well as progression of numerous disorders such as type 2 diabetes and Parkinson disease

However, a rather dramatic clinical picture can develop upon ingestion of fava beans (favism), during the course of infection, or after exposure to certain oxidative agents (see Table 18-3 )

Care 10 (1), e002363

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Perhaps the weight of factors causing oxidative stress peaked during the height of the industrial revolution and has since declined from that peak, 9 but this is unknown