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The identified BA metabolites in brain contain both primary BA synthesized in the liver and secondary BA converted in intestinal by microbiota

& Vierling, J

Accordingly, whenever we talk about blood pressure in healthcare, we are typically referring to the pressure of blood in arteries

This review summarizes recent findings highlighting the metabolism, crosstalk between brain and periphery, and neurological functions of BA to elucidate the important role of BA signaling in the brain under both physiological and pathological conditions