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However, in oxidative stress or metabolic alteration the electrophiles- and ROS-induced oxidation and modification of KEAP1 sensor cysteines lead to inhibition of KEAP1-mediated Nrf2 degradation and thereby Nrf2 accumulates in the nucleus and activates cytoprotective and metabolic genes [167,168]

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References Ahmed KSZ, Ahmed SSZ, Thangakumar A, Krishnaveni R (2019) Therapeutic effect of Parmotrema tinctorum against complete Freunds adjuvant-induced arthritis in rats and identification of novel isophthalic ester derivative

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