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(2020) discovered artesunate inhibited the growth of cultured Merkel cell polyomavirus (MCPyV)-positive MCC cell lines effectively, and artesunate-induced cell death in investigated MCC cell lines can be significantly reduced by ferrostatin-1, deferoxamine and rosiglitazone (an inhibitor of the ACSL4)

Collectively, work across multiple independent laboratories have reported on both amyloid and tau transgenic AD mouse models, postmortem human brain tissue from two distinct tau-expressing neurodegenerative conditions, and three senolytic compounds (Table 1)

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The significance of these antioxidants extends beyond simple radical neutralization