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All animal procedures related to were approved by the Johns Hopkins University Animal Care and Use Committee
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451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig
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Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptors
