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This calcium-SM interaction helps maintain cellular integrity under salt stress

F., Eaton, E

A Randomized, Double-blind, Placebo-controlled Parallel Group Phase 2a Study to Evaluate the Efficacy and Safety of HPG1860 in Subjects With Nonalcoholic Steatohepatitis (2022)

Importantly, oxidative stress markedly increases mucus cross-linking, making mucus more viscous and difficult to clear [77] and may account for the widespread mucus plugging seen in some patients with severe COPD [78]

To identify compounds that interfere by all four of the mechanisms listed above, it is necessary to perform the assay by two separate methods