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Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

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In a breast cancer xenograft model (MDA-MB-231), mitochondria-targeted nanomedicines co-assembled from berberine and doxorubicin effectively repairs mitochondrial protein defects (Mfn1/Drp1) and inhibits the activity of MMP-2 and MMP-9, resulting in significant suppression of tumor cell proliferation and lung metastasis [242]

It has become more tangible ever since, but perhaps in a different way than might have been expected back then