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Blockage of autophagy using the late-stage autophagy inhibitor bafilomycin A1 was shown to reduce STING degradation leading to enhanced downstream signaling and improved anti-tumor response (268)

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Biologics that block IL-17 or IL-23 can clear skin dramatically because they shut off the signal at its source (Hawkes et al., J Allergy Clin Immunol, 2017)

Except for 16S rRNA sequencing, all in vitro studies were based on at least three repeats and in vivo data on 510 mice per group with at least two independent repeats to achieve significant differences