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The signal enabled the authors to distinguish between the two heart failure phenotypes since the long-chain ACs were higher in those with reduced ejection fraction (HFrEF) compared to the subjects with preserved ejection fractions (HFpEF)

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J Card Fail (2017) 23:66671
this can lower burning or shooting pain within a few days, with best relief after 12 weeks of steady use

Moreover, the results of this study led to the approval of 23 mg/d donepezil for patients with moderate-to-severe AD in 2012
