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This led to the development of compounds irreversibly interacting with EGFRm/T790M, such as afatinib, 324674 and more recently AZD9291 and CO1696 [1012]

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Weihong Zhang, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Models should be developed to recapitulate the conditions and timing of treatment in the clinical context, and the mechanism for relapse should eventually guide possible treatment strategies

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