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A., Yazdanbakhsh M., Wierenga E

In light of this, Mendelian randomization (MR) analysis appears as a promising method for examining the causal relationship between mitochondrial dysfunction and DKA ( MR analysis is a causal inference method that uses genetic variations as instrumental variables (IVs) ( 2 Materials and methods 2.1 Study design and data source By combining MR analysis and bioinformatics enrichment analysis, we explored potential regulatory mechanisms between mitochondria and DKA in this study

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They are found in low concentration under normal physiological states, but accumulate in conditions where cells undergo physiological stress [3]