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Key findings were that elevation of free copper in blood is due to impaired biliary excretion in Wilson disease and that this free copper is responsible for copper accumulation in different organs

[PubMed: 15528470] 410

Hoober, K

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"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance." Diabetologia
