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The potential therapeutic regimen for overcoming resistance to osimertinib due to rare mutations in NSCLC

[DOI] [PMC free article] [PubMed] [Google Scholar] Gonzlez N., Iloro I., Soria J., Duran J

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Specifically, attenuation of MAPK pathway activation may contribute to the reduction of inflammatory and stress responses following irradiation, whereas regulation of Rap1-associated signaling may be involved in the maintenance of adherens junction-related proteins, including -catenin and E-cadherin, thereby supporting intestinal barrier integrity

It also supports the ammonia recycling process and the metabolism of nitric oxide