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4 Vitamin B3 Vitamin B3, commonly known as niacin, is predominantly found in meats, cereals, dairy products, fish, and eggs, and the recommended daily intake for niacin ranges from 15 mg/day to 20 mg/day for humans ( Niacin is crucial for the biochemistry of the nervous system, playing a significant role in energy metabolism, antioxidant activities, and the synthesis of essential molecules for neuronal function, such as acting in dopamine synthesis ( Nicotinamide adenine dinucleotide (NAD) is a co-substrate for various enzymes, such as sirtuins, polymerases, and cyclic ADP-ribose synthesis ( Niacin also contributes to the synthesis of neurotransmitters, such as serotonin, a derivative of tryptophan, which is pivotal for mood regulation and various neurological functions, such as sleep and appetite, besides impacting cognitive and executive functions (50)

To determine the direct link between the modulation of STAT3, G6PD or TrxR1 functions and the induction of ROS, we used siRNA to knockdown each of the three genes and measured ROS levels

The results of this study will be presented at the 80th Annual Meeting of the Japan Society of Nutrition and Food Science*3, to be held from May 15 to May 17, 2026, and have been accepted for publication in the international scientific journal Nutrition Research.*4 *1 An amino acid found in abundance in plants of the Cucurbitaceae family, has been reported to support blood flow and help maintain vascular flexibility