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Baseline symptoms were compared with identical cat allergen exposure 4 to 5 months later

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The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize

Finally, quite recently, typical neuroleptics, haloperidol and fluphenazine, atypical neuroleptics, clozapine, risperidone, olanzapine, quetiapine, and aripiprazole, antiemetic peripherally acting, domperidone, and dopamine indirect agonist amphetamine as a common effect have occlusion/occlusion-like syndrome [54]

Some users experience mild nasal irritation, particularly with initial use