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Therefore, this material is best suited for controlled research workflows and analytical applications

There is insufficient evidence for the use of B12, beyond correction of deficiency, in cognitive impairment, depression and fatigue

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Supplemental material Intervention and placebo The active substance of vitamin B 12 given in the study is 2 mL mecobalamin (5 mg/ml), administered intramuscularly.25 Placebo substance is 2 mL sodium chloride (9 mg/ml), isotonic solution for parenteral use (Baxter) intramuscularly.26 All participants are informed that their urine may turn red, which may occur during mecobalamin injections

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