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Nitric oxide can act as both inflammatory mediator and RNS, either directly or through peroxynitrites generated by its interaction with O 2 - [6, 7]

HIF, Hypoxia Inducible Factor

1 H NMR (400 MHz, DMSO-d6) = 10.49 (s, 1H), 8.67 (dd, J = 5.2, 1.8 Hz, 1H), 8.00 (td, J = 7.7, 1.9 Hz, 1H), 7.92 7.83 (m, 2H), 7.66 (d, J = 8.1 Hz, 1H), 7.51 (ddd, J = 7.3, 4.8, 1.1 Hz, 1H), 7.06 6.89 (m, 2H)

Finally, the insertion of Sec at the UGA codon is facilitated through the recognition of a unique selenocysteine insertion sequence (SECIS) present in the three prime untranslated region (3-UTR) of mRNAs of seleno-GPxs by ribosomes with the help of SECIS binding protein (SBP)

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