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[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Arroyave-Ospina JC, Wu Z, Geng Y, Moshage H

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Limitations: Clinical data is lacking and the studies presented have few participants, thus making it difficult to establish hard clinical evidence-based recommendations

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Age-Related Tissue Changes Research Emerging research areas include aging investigation: Age-Related Decline Studies: Research on GHK-Cu levels decreasing with age and functional consequences Skin Aging Research: Investigation of dermal thickness, elasticity, and appearance changes Tissue Maintenance Studies: Research on ECM turnover and tissue homeostasis Regenerative Capacity Investigation: Studies examining tissue repair capability in aged contexts Anti-Aging Mechanisms: Research on cellular and molecular changes during aging that GHK-Cu influences Research in this area examines GHK-Cu effects in aged cells, senescence models, and aged animal tissues

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