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Jun 21 2021;9(6)doi:10.3390/healthcare9060779

10.1016/j.pharmthera.2007.07.006 7 Alescio-LautierB.PabanV.Soumireu-MouratB

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Conclusion In this review, we have provided an extensive overview of the main questions that remain unanswered regarding the molecular pathogenesis of SCA3, and what does the extensive and high-quality research so far teach us on the more likely initial events that compromise cellular function

Crucially, this diabetes-induced gut microbiota dysbiosis may profoundly adversely affect the ENS and impede GI motility, as evidenced by recent mechanistic investigations ( Figure 2 )