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doi: 10.1007/S00253-011-3557-Z 35 ComaV

In the case of curcumin, there are a number of barriers to bioavailability to consider: Curcumin is unstable Curcumin is stable within the acidic environment of the stomach but becomes increasingly unstable as it enters the alkaline environment of the small intestine
Interoceptive signals may reach the brain in many ways

Farmer DT , Patel P, Choi R, Liu CY, Crump JG

It also slows digestion, helping you feel full for longer after eating
