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They constructed six progressive deletion mutants within the extra sequence region with altered autoprocessing capabilities and variable catalytic activities (Chi et al., 2014)

[DOI] [PubMed] [Google Scholar] 43.Sinha R., Sinha I., Calcagnotto A., Trushin N., Haley J.S., Schell T.D., Richie J.P., Jr

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Evaluation of SHC4H+h v -induced mitophagy regulation and mitophagy stress Hypoxia and elevated ROS levels in mitochondria trigger cellular mitophagy, where HCQ disrupts lysosomal function by raising lysosomal pH, hindering enzymatic activity, thus blocking autophagosome degradation and inducing mitophagy stress (Fig