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Paradoxically, while angiogenesis is initiated to alleviate hypoxia, the resulting vasculature frequently fails to resolve oxygen deficiency, thereby creating a vicious cycle of persistent hypoxia and continued HIF activation (165)

This work was funded by the NIH (K22ES012264, R01CA152063 R01CA241554), a Voelcker Fund Young Investigator Award, CPRIT (RP150445), Stand Up 2 Cancer-Cancer Research UK (RT6187) and GCCRI pilot funds to A.J.R.B

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In addition to the well-documented systemic and behavioral effects, recent advances highlighted Pb exposure can disrupt key molecular targets in the brain, particularly glutamatergic neurotransmission directly interacting with NMDA and AMPA ionotropic receptors