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In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [8890]

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however, the effect was biphasic, progressing to an eventual APD decrease within 15 min of treatment (Xu and Rozanski, 1998)

FEBS Lett 18:3337 [DOI] [PubMed] [Google Scholar] Weber P, Bendich A, Schalch W (1996) Vitamin C and human health-a review of recent data relevant to human requirements