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PROTACs typically occupy the beyond-Rule-of-Five (bRo5) chemical space, characterized by high molecular weights (7001200 Da), elevated lipophilicity, and suboptimal numbers of rotatable bonds (nRotBs), polar surface area, hydrogen bond donors (HBD), and acceptors (HBA) 223,224

Flow cytometry for sub-G1, active caspase-3 and H2AX analysis 1.5 10 5 cells were plated in a 12 multi-well plate and incubated with 3 M cisplatin for 6, 24 and 72 h

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Resveratrol improved behavioral, biochemical, and histopathological changes in the AD mouse model [82]

MG Traber, JF Vitamins C and E: beneficial effects from a mechanistic perspective