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in these scenarios, oxidative stress plays a major role

Excess iron, or iron that is not safely compartmentalised within cells can promote the production of reactive oxygen species (ROS) through the Fenton reaction, which in turn promotes intracellular lipid peroxidation and ultimately ferroptosis

In MR, genetic variants are applied as instrumental variables (IVs) to access the potential causal relationship between exposure and outcome due to the random distribution of these variants during meiosis ( Materials and methods Study design An overview of the bidirectional and unidirectional two-sample MR designs is presented in Figure 2

Among these approaches, nanoparticle-mediated combination therapy emerges as the most potent strategy, particularly for drug-resistant cancers (254)

This includes the production and recycling of antioxidants like glutathione
