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Briefly, thiols were derivatized with 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate, and chromatography was carried out on a C18 reversed-phase column with a mobile phase of 0.1 M potassium phosphate buffer (pH 2.1) with 5 % (vol/vol) acetonitrile

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Since then, a PEGylated form of filgrastim, pegfilgrastim, was developed to prolong the plasma half-life and improve the dosing regimen

Diabetes Complications 30 , 738745 (2016)

Ferreira RR, Carvalho RV, Coelho LL, Gonzaga BMdeS, Bonecini-Almeida MdaG, Garzoni LR, Arajo-Jorge TCde (2024) Current understanding of human polymorphism in selenoprotein genes: a review of its significance as a risk biomarker