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Description
L., Bjornholm, M., Munzberg, H
A proposed role of AOX is to act as an antioxidant, reducing the possibility of ROS production
PMID: 30032208
In particular, NRF2 strongly activates cystine uptake coupled with glutamate excretion and glutathione synthesis, which increases consumption of intracellular glutamate
Relative to the interface of oxidative stress with the formaldehyde detoxification pathway, glutathione, a main substrate for the antioxidant activity of glutathione reductase in the oxidative pathway [10] [14] , binds with formaldehyde, which is the first step in clearing of formaldehyde [15]
