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The major challenge is to balance activating CICD pathways without inducing harmful responses, such as inflammation, immune evasion, and therapy resistance (Zhao et al

Several other MAPKinases, including P38 and JNK, also drive specific cell cycle responses following extracellular stimuli

Methodologically, 3-nitrotyrosine is a useful but not fully specific footprint (requires LC-MS validation and protein-level mapping) and boronate-based probes detect ONOOH and H 2 O 2 unless kinetic discrimination and scavenger controls are used (Benhar et al

London: Elsevier

This exclusion was based on the following rationale: two studies (Esmaily et al., 2015