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In this article, we will make a short review of LDL metabolism, discuss the discordance between LDL-C and LDL-P, outline the atherogenic mechanisms of action of LDL by focusing on sdLDL and ox-LDL, summarize the methods used for measurement of LDL subclasses, and conclude the advances in LDL-lowering therapies using statins and PCSK9i

Over time, LDLs form a plaque buildup in your arteries, narrowing them and increasing your risk of heart disease, stroke, and other cardiovascular complications

Each LPS molecule is composed of Lipid A, a core polysaccharide, and an O side chain that is composed of sugar molecules that comprise the external face of the LPS ( Figure 2.19 )