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Although there is no need to pursue high industrial-grade yield, the requirements for purity are extremely strict--structural research often requires 95%, and enzyme activity experiments must be at least 90%

Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, et al

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For example, NETs contribute to thrombosis and activate macrophage NLRP3 inflammasome, while EVs can increase endothelial permeability and stimulate the production of inflammatory mediators
