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Current protocols recommend treating patients with an initial dose of 150 mg/kg NAC, infused over a period of an hour, upon hospitalization, followed by decreasing amounts of NAC infused over the next 20 hours [1]

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This proposition builds on Booth and colleagues' finding that there is a significant increase in vitamin K-dependent matrix Gla protein (MGP) expression in the lungs of IPF patients, indicating potential vitamin K deficiency (191)