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226 Moreover, HIF activation promotes cell proliferation and inhibits apoptosis in renal IR-induced AKI, and these effects can be reversed by treatment with the -catenin inhibitor IWR-1-endo, indicating interaction between HIF and the Wnt/-catenin signaling pathway in providing renal protection

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2021;18(12) doi: 10.1002/cbdv.202100433

For example, Crizotinib, an oral selective small-molecular tyrosine kinase inhibitor, is an effective anti-cancer medicine but with poor activity against brain tumor metastases due to its low BBB penetration

Trends Plant Sci 26:7082 Zhu B, Zheng S, Fan W, Zhang M, Xia Z, Chen X, Zhao A (2022) Ectopic overexpression of mulberry MnT5H2 enhances melatonin production and salt tolerance in tobacco