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Notably, TPL reverses the silencing of pro-apoptotic genes through epigenetic reprogramming and weakens cellular stress defense mechanisms by suppressing HSP70 expression

p16 INK4a is a cell cycle inhibitor that blocks CDK4/6 activity, preventing cells from progressing from the G1 phase to the S phase of the cell cycle

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The first view is that MTF-1 acts as a metal sensor that cannot bind to DNA in the absence of metals (Gnther et al., 2012)

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