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Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons

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Wang R, Wang Y, Qu L, et al

840 In addition, a mutant STR was introduced to enhance incorporation of the halo-l-tryptamines generated from the native tryptophan decarboxylase (TDC)

However, a recent study that used our patent information 18 , which was published while this manuscript was under review, reported the inhibitory potency of SC-919 against IPMK [IPMK/IP6K1 IC 50 ratio of SC-919 (LI-2124 in their report) = 82] 40 , indicating that SC-919 is selective for IP6K