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Description
5-Amino-1MQ is the lead potent, selective small-molecule inhibitor of NNMT identified to date
45 46 47 In these situations, expert opinion suggests that clinicians consider discussing with their patients a therapeutic trial of B 12 injections
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Cobalamin-dependent methionine synthase is a modular protein
By inhibiting NNMT, 5-Amino-1MQ aims to elevate intracellular levels of nicotinamide adenine dinucleotide (NAD+), a coenzyme absolutely fundamental for cellular energy metabolism, DNA repair, and overall cellular function
