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Description
Glycogen synthase kinase 3 (GSK3) in tumorigenesis and cancer chemotherapy
GCE, glassy carbon electrode

Subsequently, MOVES-PD global study was undertaken in order to assess safety, tolerability and efficacy of venglustat, a brain-penetrant allosteric glucosylceramide synthase inhibitor known also as GZ/SAR402671
The 1st glutathione-interaction site should be frequently (although transiently) occupied by GSH at millimolar concentrations, whereas diverse non-glutathione disulfide substrates are far less abundant in vivo and should encounter the active site less frequently

Ahmed, R