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Although exogenous methylglyoxal addition resulted in accumulation of proteins with MG-H1 adducts, expression levels of the catalytic subunit of glutamate-cysteine ligase (GCLC) involved in GSH synthesis remained unchanged (Supplementary Fig

Diuretics and carbohydrate metabolism: the effects of furosemide and amiloride on blood glucose, plasma insulin and cations in the rat

Consequently, further elucidation of Gln metabolic profiles and the utilisation of carriers, enzymes, or metabolites during aberrant energy metabolism as potential targets for cancer therapy would be expected to improve patient prognosis

In addition to better results in antiproliferative assays compared to the inhibitor ibrutinib, PROTAC 83 showed good metabolic stability with a half-life time of more than 145 min 98