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Common reasons include: Pernicious anemia , an autoimmune condition affecting intrinsic factor production Gastrointestinal disorders, such as Crohns disease or celiac disease Prolonged use of certain medications, like proton pump inhibitors Knowing these causes helps spot at-risk people

Patients focused on long-term metabolic health sometimes pair MOTS-c with GHK-Cu, a copper peptide that targets tissue repair, collagen production, and anti-aging at the cellular matrix level through a completely separate mechanism

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