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Description
A randomized, double-blind, placebo-controlled, stratified trial of riluzole 100 mg daily, given as 50 mg twice daily, demonstrated a statistically significant survival benefit at 12 and 21 months, with median survival increasing by 83 days [113], with more robust survival effect seen in patients with bulbar onset disease
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Concretely, enhanced glycolysis in PCa cells leads to HIF-1 lactylation, upregulating KIAA1199, accompanied by increased secretion of VEGFA, ultimately advancing angiogenesis and vasculogenic mimicry
doi: 10.1186/s12920-023-01666-w 248 RiveraCAWheelerMDEnomotoNThurmanRG
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