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Ang IV and related analogues are susceptible to proteolytic cleavage of the peptide bond between the Val 1 and Tyr 2 amino acid residues

Dong Rak Kwon and GI Young Park, Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model, Annals of Clinical and Laboratory Science, Volume 45, July-August 2015

Muti P, Quattrin T, Grant BJ, et al

Complementarily to this, our experiments also demonstrate that once ECM transfer is blocked at PAJs, interstitial fibroblasts remain inactive even after lung injury and refrain from depositing matrix