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It helps the body safely metabolize "dirty" estrogens that contribute to breast tenderness and mood swings

Lack of Nrf2 in this model also restored basal protein oxidation levels (measured by an increase in 4-hydroxynonenal modification, a byproduct of lipid peroxidation)

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Feldman E.L., Callaghan B.C., Pop-Busui R., Zochodne D.W., Wright D.E., Bennett D.L., Bril V., Russell J.W., Viswanathan V

10.1039/c7cc00045f 10.1039/c7cc00045f [DOI] [PubMed] [Google Scholar] Huber W (1981) Orgotein(bovine Cu-Zn superoxide dismutase), an anti-inflammatory protein drug: discovery, toxicology and pharmacology

Discussion Our results suggest that GSH depletion induces ferroptosis, autophagy, and SIPS in RPE cells