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In the case of other hyperpigmented lesions such as oral melanotic macule and physiological pigmentation, melanin is transferred from dendritic epidermal melanocytes to epidermal keratinocytes that form the epidermal melanin

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Where We Are Now: Research and Emerging Use Cases While the scientific interest in MOTS-c is high, clinical adoption remains limited due to the early stage of research

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Binding of norepinephrine, angiotensin II or endothelin-1 activates GPCRs, resulting in release of a dissociation inhibitor of RhoA, which then in turn activates ROCK