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Never pool multiple vials into a single containerthis introduces additional contamination risk and makes precise dosing impossible

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Weeks 5 through 8: optimization phase Increase to 20 to 22.5 units daily (4.0 to 4.5mg total)

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Some evidence supports that PI3K/AKT and ERK act downstream of TGF-, too 22,52

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Do not use during active cancer treatment

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