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doi: 10.7150/thno.66663 47 KapralovAAYangQDarHHTyurinaYYAnthonymuthuTSKimRet al

The two immunosuppressive effects of this metabolic process are as follows: tryptophan deficiency causes T-cell cycle arrest, while kynurenine and its metabolites directly poison T cells and natural killer cells (NKCs), preventing T-cell proliferation and encouraging the development of Tregs ( There are two known isoforms of IDO: IDO1 and IDO2

These sequences were then integrated using a phylogenetic tree-based clustering approach

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* Correspondence: Gen Ohtsuki, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
