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By using only the fat-reducing portion of the full hormone, researchers can investigate adipose tissue metabolism without confounding effects on IGF-1 or glucose homeostasis

Antioxid Redox Signal 10:15011513

This process requires adequate lysosomal acidification through V-ATPase activity, which depends on ATP predominantly generated by mitochondria (Schwertz and Middleton, 2023)

Nonetheless, some peptides/proteins have advanced through drug development, as shown in Table 4
