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Gilliland, R

By donating a methyl group in the methionine cycle, 5-MTHF regenerates methionine from homocysteine (HCY) in a reaction catalyzed by methionine synthase (MTR) using cobalamin (vitamin B12) as a cofactor [28,31]

Discontinue use if irritation develops
Therefore, it seems that in tobacco, OTC can induce plant defense responses like NtPR-1a expression to a similar extent as SA, suggesting that OTC, possibly via GSH, can activate the same plant defense signaling pathway as SA

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