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Acknowledgements This work was funded by the National Science Foundation (EAR-1703087, EAR-1702946), conducted with permits issued to the PJvH from Bahamas Environment and Science and Technology Commission, technical support by A

Evidence-based effects of key nutrients After understanding the pathological connection between nutrients and OA and discovering the significant role of the metabolism-inflammation-oxidative stress network in it, this study explores key nutrients that can prevent or treat OA through evidence-based medicine and reveals the mechanisms by which they exert preventive or therapeutic effects (Table 1)

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Purpose and Benefits of the Vitamin Injection Consent Form This form serves multiple purposes, primarily protecting patient rights while ensuring informed consent is obtained

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