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Bromelain has been extensively studied for its implication in cell death, indeed it can intervene in the expression of Bcl-2, a type of protein with an anti-apoptotic effect but can also positively regulates the expression of apoptotic genes, such as Bax, Apaf-1, and caspases-9 and -3 (87)

in questa fase che si parla spesso di collagen banking , cio la strategia di accumulare riserva funzionale di collagene prima che il declino diventi evidente

Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, akt, and FOXO1

The cumulative consequence of these additive effects is an increased bleeding risk