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7 Therapeutic potentials of targeting hepatic mitochondrial-related factors We summarize how hepatic mitochondrial-related factors act as a central hub influencing systemic organ function in aging and aging-related metabolic diseases, with an emphasis on their translational potential (Table 1)

Nat Commun 11(1):3427 Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D, Bai X (2018) Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

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