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The binding of the cobalamin-IF complex is selective and rapid and requires Ca 2+ , but it is not energy dependent

Although 12 h incubation with biotin was enough to label some interactors, we chose to perform all experiments using 24 h incubation to maximise the detection of weak and low abundance proximity proteins, and the potential to identify cargo proteins transiting through the sub-domains (Supplementary Fig

Those seeking quick, at-home delivery may prefer the nasal route, while patients needing precise dosing under supervision might opt for clinic-administered injections

Smallwood HS, Duan S, Morfouace M, Rezinciuc S, Shulkin BL, Shelat A, et al

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